Gene Therapy: The future

Cancer is something that has been rapidly spreading like wildfire in the last 30 years or so. It affects us and the people whom we love and it can leave us disabled. Not knowing if we may get it from our bloodline or is we can get it from the environment that we live in. Quite frankly, it’s hard to escape that. You see its hard to avoid because we have to eat, breathe air, and we have to have shelter. There are some people who will swear up and down that cancer is 100% based on our lifestyle. It’s true to a certain extent, but also people have to also look at the statistics from 30-50 years ago when it was rare to get cancer. Our weight has changed as every one in the 70’s and 80’s era was thin. You can’t help to think that processed foods ,including GMO food , has something to do with this phenomenon. The way we grow food has evolved and the way we process food is different than 40 years ago.

There is cancer all around us and it seems that now a days people can easily name two or three people close to them that has this blood sucking disease. There is no cure for cancer at this time, but currently there is research that is going on presently to find a cure. One of the methods that are being used at this time is gene therapy for cancer. “Gene therapy is is an experimental technique that uses genes to treat or prevent disease.”(“Gene Therapy”, 2017). It’s regulated to a certain extent. “Generally, gene therapy can be categorized into two categories — germ line gene therapy and somatic gene therapy. The difference between these two approaches is that in somatic gene therapy genetic material is inserted in some target cells, but the change is not passed along to the next generation, whereas in germ line gene therapy the therapeutic or modified gene will be passed on to the next generation. This difference is of importance, since current legislation allows gene therapy only on somatic cell” (“History Of Gene Therapy”, 2017).Just recently in the news, the biggest pharmaceutical company, Pfzier, announced that they will roll out gene therapy medications.”In gene therapy, new genetic material is introduced into the body to correct a patient’s cells as needed”(“Gene Therapy Finally Here Who Will Pay”, 2017).

You see genes play an important part of who we are and is quite a sensitive , because one missing code or defect can result in death.  Some people will be willing to experiment with these drugs to fix what is defect give in their genetic code. But this all comes as a price. “GlaxoSmithKline’s Strimvelis can cure the genetic disease and save precious lifes. But the $700,000 drug had only a couple of sales in 2016 and another two expected this year.”

When it comes to gene therapy is more targeted towards cancer. “The potential of gene therapy for cancer follows logically from the fact that cancer arises as a result
of single or multiple genetic alterations. Normal cells in the body follow a systematic sequence of events of growth, division and death. Unlike regular cells, cancer cells, generated due to several environmental causes and genetic aberrations, do
undergo apoptosis, or programmed cell death and instead continue to undergo growth and division.”(“Potential Therapeuticmodalities”, 2017).

“Although only two licensed cancer gene therapy products have been developed during the past 20 years, there is now a confluence of forces that should ensure substantially greater success in the next 5 years. Commercial groups have recognised that advances in our understanding of cancer biology are needed to develop more individualised targeted therapies that have high efficacy in identifiable patient subpopulations, and whose improved pharmacoeconomics enable sufficient reimbursement to justify development and distribution. Increasing clinical successes with gene-modified cell therapies such as CAR-T cells, which are producing 25-50% complete and sustained responses in early-phase clinical trials in advanced malignant diseases, predict wider acceptance of this approach to enhance host resistance to cancer. These advances, coupled with an improved understanding of vaccine technologies (including virotherapies) and the availability of monoclonal antibodies able to block signals that downregulate the immune response, are a potent combination, in which genetically modified cells targeted to tumours are stimulated in vivo by genetically modified tumour vaccines and further enhanced by antibodies that block immune inhibition. As investigators progressively exploit the potential synergies of cancer gene therapy, together with one or more of the safety switches established in clinical practice, we can expect increased success in this discipline. The challenge then will be to ensure that a sufficient cadre of skilled therapists will be available to deliver these novel products as they emerge from clinical trials.”(“Is cancer gene therapy an empty suit?” 2017).

Hopefully someday there will be a cure for cancer and we are on the right path when it comes to genetic testing. I believe this should be the only use for gene therapy when is comes to cancer and ailments. Because if gene therapy is used for curosity ,which some scientist are naturally, we might as well kiss organgic humans good bye and say hello to the new generation of carbon copies.

 

References

1)https://ghr.nlm.nih.gov/primer/therapy/genetherapy

2)http://palmettobusinessdaily.com/stories/511178860-pfizer-to-expand-in-sanford-for-gene-therapy-medications

3)http://wallstreetpit.com/113936-gene-therapy-finally-here-who-will-pay/

4)Wirth, T., Parker, N., & Ylä-Herttuala, S. (2013). History of gene therapy. Gene, 525(2), 162-169. doi:10.1016/j.gene.2013.03.137

5)Sinha, P., Kapoor, S., Kadam, S. S., Sahu, N. K., & Jaiswal, A. K. (2017). Potential therapeutic modalities in cancer gene therapy. Journal of Krishna Institute of Medical Sciences University, 6(2), 3-18.

6)Brenner, M. K., Gottschalk, S., Leen, A. M., & Vera, J. F. (2013). Is cancer gene therapy an empty suit? Lancet Oncology, 14(11), e447-56. doi:http://dx.doi.org/10.1016/S1470-2045(13)70173-6

 

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Wishing you a Happy Years!

imageHappy New Years everyone !!!

I took this picture of my glass of Opus One- and to be honest it didn’t taste any better than my Trinitas wine.

I took a break from the blog cause I have been on cloud 9 for the past few months 🙂

Its been a long time coming. Also had a creative block for a while- so readjusting myself and becoming more focused so I can finish these books I’ve been working on.

I hope everyone wishes for the new year comes true!  I think mine have came true

………To Be Continued……

Envy

I find one trait that is the most unattractive trait ever, and its envy.

Where does it come from? Why does it come from those whom we love or we’re very close to?

Coming up, my grandmother taught me that not everyone is your true friend.And I find that to be so true. I was raised to work hard to obtain the things I wanted. Taking things that didnt belong to me was out of question, which brings up the question why anyone would do this to another person. All things are attainable , you have to work for it or on it. I notice that when a person is unhappy they want other people around them miserable or be “beneath them”. Thus giving them a superior mind frame. When the plan doesn’t go right they will find ways to destroy you ,your career, or marriage/relationship .

Maybe the other person can’t bear the thought of you out suceeding them. Move out of their path and watch out for the pitfalls. Walk around them like the road runner and let Wilde fall in his own trap 😉

Awakening to god’s plan

Memories are like pictures. We keep them and store them away. Years later we can open the box and be filled with joy. Remembering the elated feeling we felt at that moment in time.

What if that memory was a blur? What if it was all in the plans of the creator? He set it up to where the only way you could unlock that part of the memory is finding that special key. The key being that special person.

You begin to wake up after a long slumber. That special person nurses you back to where you were. You remember and suddenly you are back where you were. In pure bliss. God makes no mistakes

Thoughts for my 50th

People say that when you make a good impression, it lasts for a long time.

I like to think that if I were not to be on this earth another day, then I made a good impression on others. A reason why I started this blog. Don’t worry, Im not sick , but I ‘m often grateful to be here after a brush with death himself.

You have no idea how precious time is until you come to face to face with that reality. Not a lot of people can live and tell that.

What I can say since then, I learned to treasure moments with my friends and family. To teach what I have learned to others, so that they may spread it to others and so on and so forth. Whether its professional or personally, I love to share my happiness and whats reality.

It’s funny to me how people think they have you all figured out just by looking at you. Judging you by pure ignorance and acting it out in a way that makes them feel superior. Look, no matter what your social , marital, gender, or professional status is, your still like everyone else and can be in a position you don’t want to be in. Those that will be eating today, can quickly fall and wont be eating tomorrow. Nothings ever set in stone. You don’t know what the person your looking down upon has been through, as there is always a story behind the cover. Especially the ones who consider themselves superior to others.

It never fails me that  the majority of the ones  who make the big bucks, seem to never really be balanced and are always unhappy in some way. The ones who are not in that same position as the” big wiggers” seem to be happy and content life despite financial woes or hardship.  Maybe having a sense of fulfillment, balance in life , and integrity can be the key.

When I was 7th grade, I use to walk by the college that I would  later attend and graduate from . I would be on my way to summer school  and I always  would looked at the steps to the college when I passed by every morning. There was a motto that just got me as it seem so powerful. There was a painting which I cant remember at this time, but above the  painting there was the motto.It said,” The truth shall set you free”. It really didn’t make sense at 12 years of age, but decades later it makes sense now. The truth will really set you free. Being who you want to become not what others tell you to do or being a slave to the dollar.

Live , Love, Laugh, and Teach 🙂